If there is no customer account just choose which bank account you want to use ie Cash Account and post as a bank receipt to Sales in the nominal (code 4000's). If you choose T1 it will work out the net and VAT figures and include them in the VAT return.
When you first set up cash register account it gives you the option if takings are vat inclusive or not. Later you should add the sales with clicking on bank than cash register on the left hand panel, when entering takings you can choose vat codes. I would not do payment on account on cash register, it makes the use of it pointless... If you use the above method it will post everything automatically to sales and vat accounts. Once you have your takings entered (cash,card,etc) you can use deposit cash option (again left hand panel)to transfer money to your bank or cash account. Whatever you set as opening balance is going to be your float in till, you can't transfer that -not accidentally- if your float is changing every so often you will have to use adjust float option.